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Novel candidate genes identified by studies in chicken lipoxygenase-1 and telomerase gene ex- pression in cancer CD47/SIRPalpha-interaction in regula-. protein, eller så kan det egna immun- försvaret angripa kroppens system. Anti-CD47/CD19. R/R B cell lymfom till diskonterat värde och har därmed gene-. 9.298932 8.671591 9.180801 9.685225 8.651528 2687739 "CD47" 10.48817 10.94405 10.39455 11.38805 10.53389 11.78077 10.98179 11.61122 10.5925 Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo.

Cd47 gene

The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. Gene name: CD47 (HGNC Symbol) Synonyms: IAP, MER6, OA3: Description: CD47 molecule (HGNC Symbol) Chromosome: 3: Cytoband: q13.12: Chromosome location (bp) 108043094 - 108091862: Number of transcripts i Methods: After the lentiviral CD47-siRNA was transfected into acute myelogenous leukemia stem cells (LSCs), the proliferative status of acute myelogenous LSCs was detected by cell counting kit-8, and the apoptosis of stem cells of acute myeloid leukemia was detected by annexin/propidium iodide flow assays. 2020-12-01 · HIF-1 directly bound with the promoter of CD47 to activate gene transcription and increased cell surface CD47 in HCC1954 and SUM159 breast cancer cells . Moreover, macrophage phagocytosis rate was significantly increased when co-cultured with HIF-1-deficient breast cancer cells [ 43 ], indicating that HIF-1 plays a pivotal role in regulation of CD47 expression.

GeneRIFs: Gene References Into Functions CD47 - CD47 molecule (human) This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal CD47 CD47 molecule Gene ID: 961, updated on 7-Mar-2021 Gene type: protein coding Also known as: IAP; OA3; MER6.

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Cd47 Name. CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Synonyms.

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Functional Associations. CD47 has 6,184 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 79 datasets. CD47 is a cell surface glycoprotein that helps mediate neutrophil transmigration across blood vessels. The present study was performed to determine whether absence of the CD47 gene decreases focal ischemic brain damage.

Gene: Cd47 - ENSMUSG00000055447 - Mus musculus (mouse) CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene.CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 and signal-regulatory protein alpha (). Gene: Cd47 - ENSMUSG00000055447 - Mus musculus (mouse) General information. Ensembl ID: ENSMUSG00000055447: Name: Cd47: Description Description: Homo sapiens CD47 molecule (CD47), transcript variant 1, mRNA. (from RefSeq NM_001777) RefSeq Summary (NM_001777): This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix.
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The protein is also a receptor for the This antibody reacts with Ig domain of CD47 protein. CD47, originally named integrin-associated protein (IAP), is a 50 kDa protein containing five CD47 är ett allestädes närvarande uttryckt transmembran protein som hämmar det medfödda immunsvaret när det är bundet till dess kongnatre av H Ågerstam · 2015 · Citerat av 67 — The interleukin 1 receptor accessory protein (IL1RAP; IL1R3) is expressed on (2009) CD47 is an adverse prognostic factor and therapeutic CENPM. 0.25. -0.26.

Species Human Transcripts. Click to View Transcript Type Non-Coding Product Type Silencer® Select Availability. Made to Order.
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Mitigation of Blood Borne Cell Attachment to Metal Implants

(from RefSeq NM_001777) RefSeq Summary (NM_001777): This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. Functional Associations.

Functions of Transcription Factor Alpha-Pal/Nrf-1 in Neurons - Alpha

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To investigate the effect of targeted inhibition of CD47 gene expression on stem cell clearance in acute myeloid leukemia.